Entertainment · October 20, 2026
Christina Applegate Says She Was Misdiagnosed With Multiple Sclerosis: ‘It’s Very Confusing’
Christina Applegate announced on her podcast, 'MeSsy', that she was misdiagnosed with multiple sclerosis (MS) five years ago. While a doctor recently informed her she does not have the disease, she continues to experience debilitating symptoms that currently lack a specific diagnosis. Applegate expressed confusion and frustration over the news, noting that she feels she unintentionally misrepresented herself while becoming a prominent advocate for the MS community. Her podcast co-host, Jamie-Lynn Sigler, offered support, emphasizing that their physical struggles remain similar regardless of the medical label.
Read the original coverage
- Rolling StoneMainstream
Christina Applegate Says She Was Misdiagnosed With Multiple Sclerosis: 'It's Very Confusing'
Read at Rolling Stone ↗ - The GuardianMainstream
Actor Christina Applegate reveals she was misdiagnosed with multiple sclerosis
Read at The Guardian ↗ - NBC NewsMainstream
Christina Applegate says she was misdiagnosed with multiple sclerosis
Read at NBC News ↗ - Us WeeklyCelebrity
Jamie-Lynn Sigler Tells Christina Applegate to Give Herself ‘Grace’ After MS Misdiagnosis
Read at Us Weekly ↗ - TMZTabloid
Christina Applegate Reveals She Does NOT Have Multiple Sclerosis
Read at TMZ ↗
Reported by multiple outlets
- Christina Applegate revealed the misdiagnosis on the podcast 'MeSsy'.
- She was originally diagnosed with MS five years prior to this announcement.
- A doctor recently told her she does not have MS.
- Applegate continues to experience debilitating physical symptoms.
- She has become a public advocate for the MS community since her initial diagnosis.
- Jamie-Lynn Sigler is her podcast co-host and remains supportive.
Reported by only some outlets
- Applegate published an emotional memoir in March regarding her health struggles.
- Applegate reported that she is back at 'square one' regarding her medical investigation.
- Sigler suggested that their bodies might be battling similar issues regardless of the name of the condition.
Confirmed
- Christina Applegate was told by a doctor that she does not have multiple sclerosis.
- The announcement was made on the October 20, 2026, episode of the podcast 'MeSsy'.
- She has suffered from symptoms attributed to MS for the last five years.
Reported
- The news of the misdiagnosis is a 'mindfuck' and leaves her at 'square one'. (NBC News and Rolling Stone (quoting Christina Applegate))
- Applegate published an emotional memoir in March regarding her struggles. (The Guardian)
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