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Entertainment · October 20, 2026

Christina Applegate Reveals She Was Misdiagnosed With MS: ‘I’m Back at Square One’ and It’s a ‘Mindf—’

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Christina Applegate announced on her podcast 'MeSsy' that she was misdiagnosed with multiple sclerosis (MS), approximately five years after her initial diagnosis. Despite the reversal of the diagnosis, Applegate reported that her debilitating physical symptoms persist, leading her to describe the situation as being 'back at square one.' The revelation came after medical monitoring of her B-cell count following the cessation of infusion treatments showed no expected changes, prompting further investigation. Applegate expressed frustration and confusion over the news, noting that the lack of a definitive diagnosis for her ongoing health issues is unnerving.

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Reported by multiple outlets

  • Christina Applegate announced she does not have multiple sclerosis.
  • The announcement was made on the October 20, 2026, episode of her podcast 'MeSsy'.
  • Applegate was originally diagnosed with MS approximately five years prior.
  • Her physical symptoms have not improved despite the change in diagnosis.
  • The misdiagnosis was discovered after doctors monitored her B-cell counts following a break from infusion treatments.

Reported by only some outlets

  • Applegate published a memoir about her struggles with chronic illness in March.
  • She was originally tested for 'everything under the sun' in 2021 before the MS diagnosis was made.
  • The initial diagnosis included brain and spinal MRIs and a spinal tap.
  • The specific initial diagnosis was Relapsing Multiple Sclerosis (RMS).

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